1.1 General anaesthetics and oxygen

ether, anaesthetic

(1c, 2)

inhalation.

halothane

(2)

inhalation.

ketamine hydrochloride

(2)

injection, 50 mg/ml in 10-ml vial.

nitrous oxide

(2)

inhalation.

oxygen

inhalation (medicinal gas).

*thiopental sodium

(2)

powder for injection, 0.5 g, 1.0 g in ampoule.

1.2 Local anaesthetics

*bupivacaine hydrochloride

(2, 9)

injection, 0.25%, 0.5% in vial; injection for spinal anaesthesia, 0.5% in 4-ml ampoule to be mixed with 7.5% glucose solution.

*lidocaine hydrochloride

injection, 1%, 2% in vial; injection for spinal anaesthesia, 5% in 2-ml ampoule to be mixed with 7.5% glucose solution; topical forms, 2-4%.

*lidocaine hydrochloride + epinephrine

injection 1%, 2% + epinephrine 1:200 000 in vial; dental cartridge 2% + epinephrine 1:80 000.

Complementary drug(s)

ephedrine hydrochloride*

(C)

injection, 30 mg/ml in 1-ml ampoule.

*To prevent hypotension in spinal anaesthesia during delivery.

1.3 Preoperative medication and sedation for short-term procedures

atropine sulfate

injection, 1 mg in 1-ml ampoule.

chloral hydrate

syrup, 200 mg/5 ml.

*diazepam

(1b)

injection, 5 mg/ml in 2-ml ampoule; tablet, 5 mg.

*morphine hydrochloride

(1a)

injection, 10 mg in 1-ml ampoule.

*morphine sulfate

(1a)

injection, 10 mg in 1-ml ampoule.

*promethazine hydrochloride

elixir or syrup, 5 mg/5 ml.

2.1 Non-opioids and NSAIDs

acetylsalicylic acid

tablet, 100-500 mg; suppository, 50-150 mg.

*ibuprofen

tablet, 200 mg, 400 mg.

paracetamol

tablet, 100-500 mg; suppository, 100 mg; syrup, 125 mg/5 ml.

2.2 Opioid analgesics

*codeine phosphate

(1a)

tablet, 30 mg.

*morphine hydrochloride

(1a)

injection, 10 mg in 1-ml ampoule; oral solution, 10 mg/5 ml..

*morphine sulfate

(1a)

injection, 10 mg in 1-ml ampoule; oral solution, 10 mg/5 ml; tablet, 10 mg.

*pethidine hydrochloride

(A) (1a, 4)

injection, 50 mg in 1-ml ampoule; tablet, 50 mg, 100 mg.

2.3 Drugs used to treat gout

allopurinol

(4)

tablet, 100 mg.

colchicine

(7)

tablet, 500 micrograms.

2.4 Disease modifying anti-rheumatoid drugs (DMARDs)

azathioprine

(2)

tablet, 50 mg.

chloroquine phosphate

(2)

tablet, 100 mg, 150 mg of chloroquine.

chloroquine sulfate

(2)

tablet, 100 mg, 150 mg of chloroquine.

cyclophosphamide

(2)

tablet, 25 mg.

methotrexate sodium

(2)

tablet, 2.5 mg.

penicillamine

(2)

capsule or tablet, 250 mg.

sulfasalazine

(2)

tablet, 500 mg.

3. ANTIALLERGICS AND DRUGS USED IN ANAPHYLAXIS

*chlorphenamine hydrogen maleate

tablet, 4 mg; injection, 10 mg in 1-ml ampoule.

*dexamethasone

tablet, 500 micrograms, 4 mg.

*dexamethasone disodium phosphate

injection, 4 mg of dexamethasone phosphate in 1-ml ampoule.

epinephrine hydrogen tartrate

injection, 1 mg of epinephrine in 1-ml ampoule.

epinephrine hydrochloride

injection, 1 mg of epinephrine in 1-ml ampoule.

hydrocortisone sodium succinate

powder for injection, 100 mg of hydrocortisone in vial.

*prednisolone

tablet, 5 mg.

4.1 Non-specific

*charcoal, activated

powder.

ipecacuanha

syrup, containing 0.14% ipecacuanha alkaloids calculated as emetine.

4.2 Specific

atropine sulfate

injection, 1 mg in 1-ml ampoule.

calcium gluconate

(2, 8)

injection, 100 mg in 10-ml ampoule.

deferoxamine mesilate

powder for injection, 500 mg in vial.

dimercaprol

(2)

injection in oil, 50 mg/ml in 2-ml ampoule.

*methionine (DL-)

tablet, 250 mg.

methylthioninium chloride (methylene blue)

injection, 10 mg/ml in 10-ml ampoule.

naloxone hydrochloride

injection, 400 micrograms in 1-ml ampoule.

penicillamine

(2)

capsule or tablet, 250 mg.

potassium ferric hexacyano-ferrate(II) (Prussian blue)

powder for oral administration.

sodium calcium edetate

(2)

injection, 200 mg/ml in 5-ml ampoule.

sodium nitrite

injection, 30 mg/ml in 10-ml ampoule.

sodium thiosulfate

injection, 250 mg/ml in 50-ml ampoule.

5. ANTICONVULSANTS/ANTIEPILEPTICS

carbamazepine

(10,11)

scored tablet, 100 mg, 200 mg.

*diazepam

(1b)

injection, 5 mg/ml in 2-ml ampoule (intravenous or rectal).

ethosuximide

capsule, 250 mg; syrup, 250 mg/5 ml.

phenobarbital

(1b, 11)

tablet, 15-100 mg; elixir, 15 mg/5 ml.

phenytoin sodium

(7, 11)

capsule or tablet, 25 mg, 50 mg, 100 mg; injection, 50 mg/ml in 5-ml vial.

sodium valproate

(7, 11)

enteric coated tablet, 200 mg, 500 mg.

Complementary drug(s)

*clonazepam

(B) (1b)

scored tablets 500 micrograms.

magnesium sulfate

(C)

injection, 500 mg/ml in 2-ml ampoule; injecton, 5 g/10 ml in ampoule.

6.1.1 Intestinal anthelminthics

albendazole

chewable tablet, 400 mg.

levamisole hydrochloride

tablet, 50 mg of levamisole, 150 mg of levamisole.

*mebendazole

chewable tablet, 100 mg, 500 mg.

niclosamide

chewable tablet, 500 mg.

praziquantel

tablet, 150 mg, 600 mg.

pyrantel embonate

chewable tablet 250 mg of pyrantel; oral suspension, 50 mg of pyrantel/ml.

6.1.2 Antifilarials

diethylcarbamazine dihydrogen citrate

tablet, 50 mg, 100 mg.

ivermectin

scored tablet, 3 mg, 6 mg.

Complementary drug(s)

suramin sodium

(B) (2, 7)

powder for injection, 1 g in vial.

6.1.3 Antischistosomals and anti-trematode drugs

praziquantel

tablet, 600 mg.

triclabendazole

tablet, 250 mg.

Complementary drug(s)

oxamniquine

(C) (8)

capsule, 250 mg; syrup, 250 mg/5 ml.

6.2.1 Beta lactam drugs

*amoxicillin (anhydrous)

(4)

capsule or tablet, 250 mg, 500 mg; powder for oral suspension, 125 mg/5 ml.

ampicillin sodium

powder for injection, 500 mg, 1 g, in vial.

benzathine benzylpenicillin

powder for injection, 1.44 g of benzylpenicillin (=2.4 million IU) in 5-ml vial.

benzylpenicillin potassium

powder for injection, 600 mg (= 1 million IU), 3 g (= 5 million IU) in vial.

benzylpenicillin sodium

powder for injection, 600 mg (= 1 million IU), 3 g (= 5 million IU) in vial.

*cloxacillin sodium

capsule, 500 mg, 1 g of cloxacillin; powder for oral solution, 125 mg of cloxacillin/5 ml; powder for injection, 500 mg of cloxacillin in vial.

phenoxymethylpenicillin potassium

tablet, 250 mg of phenoxymethylpenicillin; powder for oral suspension, 250 mg of phenoxymethylpenicillin/5 ml.

procaine benzylpenicillin

powder for injection, 1 g (=1 million IU), 3 g (=3 million IU).

Reserve antibacterials

*amoxicillin + *clavulanic acid

(D)

tablet, 500 mg + 125 mg.

ceftazidime pentahydrate

(D)

powder for injection, 250 mg of ceftazidime in vial.

*ceftriaxone sodium

(D)

powder for injection, 250 mg of ceftriaxone in vial.

imipenem + cilastatin sodium

(D)

powder for injection 250 mg + 250 mg, 500 mg + 500 mg in vial.

6.2.2 Other antibacterials

*chloramphenicol

(7)

capsule, 250 mg.

*chloramphenicol palmitate

(7)

oral suspension, 150 mg of chloramphenicol/5 ml.

*chloramphenicol sodium succinate

(7)

powder for injection, 1 g of chloramphenicol in vial.

*ciprofloxacin hydrochloride

tablet 250 of ciprofloxacin.

*doxycycline hyclate

(5, 6)

capsule or tablet, 100 mg of doxycycline.

*erythromycin ethylsuccinate

capsule or tablet, 250 mg of erythromycin; powder for oral suspension, 125 mg of erythromycin..

*erythromycin lactobionate

powder for injection, 500 mg of erythromycin in vial.

*erythromycin stearate

capsule or tablet, 250 mg of erythromycin; powder for oral suspension, 125 mg of erythromycin.

*gentamicin sulfate

(2, 4, 7, 11)

injection, 10 mg, 40 mg of gentamicin/ml in 2-ml vial.

*metronidazole

tablet, 200-500 mg; injection, 500 mg in 100-ml vial; suppository, 500 mg, 1 g.

*metronidazole benzoate

oral suspension, 200 mg of metronidazole/5 ml.

nalidixic acid

(8)

tablet 250 mg, 500 mg.

nitrofurantoin

(4, 8)

tablet, 100 mg.

spectinomycin hydrochloride

(8)

powder for injection, 2 g of spectinomycin in vial.

*sulfadiazine

(4)

tablet, 500 mg.

*sulfadiazine sodium

(4)

injection, 250 mg in 4-ml ampoule.

*sulfamethoxazole + trimethoprim

(4)

tablet, 100 mg + 20 mg, 400 mg + 80 mg; oral suspension, 200 mg + 40 mg/5 ml; injection, 80 mg + 16 mg/ml in 5-ml and 10-ml ampoules.

trimethoprim

(8)

tablet, 100 mg, 200 mg; injection 20 mg/ml in 5-ml ampoule.

Complementary drug(s)

chloramphenicol sodium succinate

(C)

oily suspension for injection 0.5 g of chloramphenicol/ml in 2-ml ampoule.

clindamycin

(B) (8)

capsule, 150 mg.

clindamycin phosphate

(B) (8)

injection, 150 mg of clindamycin.

Reserve antibacterial

vancomycin hydrochloride

(D)

powder for injection, 250 mg of vancomycin in vial.

6.2.3 Antileprosy drugs

clofazimine

capsule, 50 mg, 100 mg.

dapsone

tablet, 25 mg, 50 mg, 100 mg.

rifampicin

capsule or tablet, 150 mg, 300 mg.

6.2.4 Antituberculosis drugs

ethambutol hydrochloride

(4)

tablet, 100 mg-400 mg.

isoniazid

tablet, 100 - 300 mg.

isoniazid + ethambutol hydrochloride

(5)

tablet, 150 mg + 400 mg.

pyrazinamide

tablet, 400 mg.

rifampicin

capsule or tablet, 150 mg, 300 mg.

rifampicin + isoniazid*

(5)

tablet, 150 mg + 75 mg; 300 mg + 150 mg; 150 mg + 150 mg.

*For intermittent use three times weekly.

rifampicin + isoniazid + pyrazinamide*

(5)

tablet, 150 mg + 75 mg + 400 mg; 150 mg + 150 mg + 500 mg.

*For intermittent use three times weekly.

streptomycin sulfate

(4)

powder for injection, 1 g of streptomycin in vial.

Complementary drug(s)

thioacetazone + isoniazid

(A) (5, 7)

tablet, 50 mg + 100 mg; 150 mg + 300 mg.

6.3 Antifungal drugs

amphotericin B

(4)

powder for injection, 50 mg in vial.

griseofulvin

(8)

capsule or tablet, 125 mg, 250 mg.

*ketoconazole

(2)

tablet, 200 mg; oral suspension, 100 mg/5 ml.

nystatin

tablet, 100,000, 500,000 IU; lozenge 100,000 IU; pessary, 100,000 IU.

Complementary drug(s)

flucytosine

(B) (4, 8)

capsule, 250 mg; infusion, 2.5 g in 250 ml.

potassium iodide

(A)

saturated solution.

6.4.1 Antiherpes

aciclovir

(8)

tablet, 200 mg.

aciclovir sodium

(8)

powder for injection, 250 mg of aciclovir.

6.4.2 Antiretrovirals

zidovudine

(8)

capsules 100 mg, 250 mg; injection, 10 mg/ml in 20-ml vial; oral solution 50 mg/5-ml.

Drugs for treatment of HIV/AIDS include Nucleoside Reverse Transcriptase Inhibitors (NRTIs), Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and protease inhibitors (PIs). The prototype drug, zidovudine, has been shown to reduce or prevent mother-to-child transmission. THIS IS THE ONLY INDICATION FOR WHICH IT IS INCLUDED HERE. Single drug use with zidovudine, except in pregnancy, is now regarded as obsolete, because of the development of resistance. Triple therapy is beyond the budgets of most national drug programmes and therefore HIV/AIDS treatment policies must be decided at country or institutional level.

6.5.1 Antiamoebic and antigiardiasis drugs

*diloxanide furoate

tablet, 500 mg.

*metronidazole

tablet, 200-500 mg; injection, 500 mg in 100-ml vial.

*metronidazole benzoate

oral suspension 200 mg of metronidazole/5 ml.

6.5.2 Antileishmaniasis drugs

*meglumine antimonate

injection, 30%, equivalent to approximately 8.5% antimony, in 5-ml ampoule.

pentamidine isetionate

(5)

powder for injection, 200 mg, 300 mg in vial.

Complementary drug(s)

amphotericin B

(B) (4)

powder for injection, 50 mg in vial.

6.5.3.1 For curative treatment

*chloroquine hydrochloride

injection 40 mg of chloroquine/ml in 5-ml ampoule.

*chloroquine phosphate

tablet 100 mg, 150 mg of chloroquine; syrup, 50 mg of chloroquine/5 ml; injection 40 mg of chloroquine/ml in 5-ml ampoule.

*chloroquine sulfate

tablet 100 mg, 150 mg of chloroquine; syrup, 50 mg of chloroquine/5 ml; injection 40 mg of chloroquine/ml in 5 ml ampoule.

primaquine diphosphate

tablet, 7.5 mg, 15 mg of primaquine.

*quinine bisulfate

tablet, 300 mg.

*quinine dihydrochloride

injection, 300 mg/ml in 2-ml ampoule.

*quinine sulfate

tablet, 300 mg.

Complementary drug(s)

*doxycycline hyclate*

(B)

capsule or tablet, 100 mg.

*For use only in combination with chloroquine.

mefloquine hydrochloride

(B)

tablet, 250 mg of mefloquine.

*sulfadoxine + pyrimethamine

(B)

tablet, 500 mg + 25 mg.

Reserve antimalarial

artemether

(D)

injection, 80 mg/ml in 1-ml ampoule.

6.5.3.2 For prophylaxis

chloroquine phosphate

tablet, 150 mg of chloroquine; syrup, 50 mg of chloroquine/5 ml.

chloroquine sulfate

tablet, 150 mg of chloroquine; syrup, 50 mg of chloroquine/5 ml.

mefloquine hydrochloride

tablet, 250 mg of mefloquine.

proguanil hydrochloride*

tablet, 100 mg.

*For use only in combination with chloroquine.

6.5.4 Anti-pneumocystosis and anti-toxoplasmosis drugs

pentamidine isetionate

(2)

tablet 200 mg, 300 mg.

pyrimethamine

tablet, 25 mg.

sulfamethoxazole + trimethoprim

injection 80 mg + 16 mg in 5 ml ampoule.

6.5.5.1 African trypanosomiasis

melarsoprol

(5)

injection, 3.6% solution.

pentamidine isetionate

(5)

powder for injection, 200 mg, 300 mg in vial.

suramin sodium

(5)

powder for injection, 1 g in vial.

Complementary drug(s)

eflornithine hydrochloride

(C)

injection, 200 mg/ml in 100-ml bottles.

6.5.5.2 American trypanosomiasis

benznidazole

(7)

tablet, 100 mg.

nifurtimox

(2, 8)

tablet, 30 mg; 120 mg; 250 mg.

6.6 Insect repellents

diethyltoluamide

topical solution, 50%, 75%.

7.1 For treatment of acute attack

acetylsalicylic acid

tablet, 300 - 500 mg.

ergotamine tartrate

(7)

tablet, 1 mg.

paracetamol

tablet, 300-500 mg.

7.2 For prophylaxis

*propranolol hydrochloride

tablet, 20 mg, 40 mg.

8.1 Immunosuppressive drugs

*azathioprine

(2)

tablet, 50 mg.

*azathioprine sodium

(2)

powder for injection, 100 mg of azathioprine in vial.

ciclosporin*

(2)

capsule, 25 mg; concentrate for injection 50 mg/ml in 1-ml ampoule.

*For organ transplantation.

8.2 Cytotoxic drugs

asparaginase

(2)

powder for injection, 10,000 IU in vial.

bleomycin sulfate

(2)

powder for injection, 15 mg of bleomycin in vial.

calcium folinate

(2)

tablet, 15 mg; injection, 3 mg/ml in 10-ml ampoule.

chlormethine hydrochloride

(2)

powder for injection, 10 mg in vial.

cisplatin

(2)

powder for injection, 10 mg, 50 mg in vial.

cyclophosphamide

(2)

tablet, 25 mg; powder for injection, 500 mg in vial.

cytarabine

(2)

powder for injection, 100 mg in vial.

dacarbazine

(2)

powder for injection, 100 mg in vial.

dactinomycin

(2)

powder for injection, 500 micrograms in vial.

*doxorubicin hydrochloride

(2)

powder for injection, 10 mg, 50 mg in vial.

etoposide

(2)

capsule, 100 mg; injection, 20 mg/ml in 5-ml ampoule.

fluorouracil

(2)

injection, 50 mg/ml in 5-ml ampoule.

levamisole hydrochloride

(2)

tablet, 50 mg of levamisole.

mercaptopurine

(2)

tablet, 50 mg.

methotrexate sodium

(2)

tablet, 2.5 mg of methotrexate; powder for injection, 50 mg of methotrexate in vial.

procarbazine hydrochloride

capsule, 50 mg of procarbazine.

vinblastine sulfate

(2)

powder for injection, 10 mg in vial.

vincristine sulfate

(2)

powder for injection, 1 mg, 5 mg in vial.

8.3 Hormones and antihormones

*prednisolone

tablet, 5 mg.

*prednisolone sodium phosphate

powder for injection, 20 mg of prednisolone in vial, 25 mg of prednisolone in vial.

*prednisolone sodium succinate

powder for injection, 20 mg of prednisolone in vial, 25 mg of prednisolone in vial.

tamoxifen citrate

tablet, 10 mg, 20 mg of tamoxifen.

9. ANTIPARKINSONISM DRUGS

*biperiden hydrochloride

tablet, 2 mg.

*biperiden lactate

injection, 5 mg in 1-ml ampoule.

levodopa + *carbidopa

(5, 6)

tablet, 100 mg + 10 mg; 250 mg + 25 mg.

10.1 Anti-anaemia drugs

ferrous sulfate

tablet, 60 mg Fe; oral solution, 25 mg Fe/1 ml.

ferrous sulfate + sodium folate*

tablet equivalent to 60 mg iron + 400 micrograms sodium folate.

*Nutritional supplement for use during pregnancy.

hydroxocobalamin

(2)

injection, 1 mg in 1-ml ampoule.

sodium folate

(2)

injection, 1 mg of folic acid in 1-ml ampoule.

Complementary drug(s)

*iron dextran

(B) (5)

injection, equivalent to 50 mg Fe (as complex of iron (III) hydroxide with dextran)/ml in 2-ml ampoule.

10.2 Drugs affecting coagulation

desmopressin acetate

(8)

injection, 4 micrograms/ml in 1-ml ampoule; nasal spray 10 micrograms/metered dose.

heparin sodium

injection, 1000 IU/ml, 5000 IU/ml, 20,000 IU/ml in 1-ml ampoule.

phytomenadione

injection, 10 mg/ml in 5-ml ampoule; tablet, 10 mg.

protamine sulfate

injection, 10 mg/ml in 5-ml ampoule.

*warfarin sodium

(2, 6)

tablet, 1 mg, 2 mg and 5 mg.

11.1 Plasma substitutes

*dextran 70

injectable solution, 6%.

*polygeline

injectable solution, 3.5%.

11.2 Plasma fractions for specific use

All plasma fractions should comply with the WHO Requirements for the Collection, Processing and Quality Control of Blood, Blood Components, and Plasma Derivatives (Revised 1992). WHO Technical Report Series, No. 840, 1994, Annex 2.

albumin, human

(2, 8)

injectable solution, 5%, 25%.

Complementary drug(s)

*factor VIII concentrate

(C) (2, 8)

(dried).

*factor IX complex concentrate (coagulation factors, II, VII, IX, X)

(C) (2, 8)

(dried).

12.1 Antianginal drugs

*atenolol

tablet, 50 mg, 100 mg.

glyceryl trinitrate

tablet (sublingual), 500 micrograms.

*isosorbide dinitrate

tablet (sublingual), 5 mg.

*verapamil hydrochloride

(10)

tablet, 40 mg, 80 mg.

12.2 Antiarrhythmic drugs

*atenolol

tablet, 50 mg, 100 mg.

digoxin

(4, 11)

tablet, 62.5 micrograms, 250 micrograms; oral solution 50 micrograms; injection 250 micrograms/ml in 2-ml ampoule..

lidocaine hydrochloride

injection, 20 mg/ml in 5-ml ampoule.

verapamil hydrochloride

(8, 10)

tablet, 40 mg, 80 mg; injection, 2.5 mg/ml in 2-ml ampoule.

Complementary drug(s)

epinephrine hydrochloride

(C)

injection 1 mg of epinephrine in 1-ml ampoule.

isoprenaline hydrochloride

(C)

injection, 20 micrograms/ml.

*procainamide hydrochloride

(B)

tablet, 250 mg, 500 mg; injection, 100 mg/ml in 10-ml ampoule.

*quinidine sulfate

(A) (7)

tablet, 200 mg.

12.3 Antihypertensive drugs

*atenolol

tablet, 50 mg, 100 mg.

*captopril

scored tablet, 25 mg.

*hydralazine hydrochloride

tablet, 25 mg, 50 mg; powder for injection, 20 mg in ampoule.

*hydrochlorothiazide

scored tablet, 25 mg.

methyldopa

(7)

tablet, 250 mg.

*nifedipine

(10)

sustained release formulations; tablet 10 mg.

*reserpine

tablet, 100 micrograms, 250 micrograms; injection, 1 mg in 1-ml ampoule.

Complementary drug(s)

*doxazosin mesilate

(B)

tablet, 1 mg, 2 mg, 4 mg.

*sodium nitroprusside

(C) (2, 8)

powder for infusion, 50 mg in ampoule.

12.4 Drugs used in heart failure

*captopril

(4, 11)

scored tablet, 25 mg.

*digoxin

(4, 11)

tablet, 62.5 micrograms, 250 micrograms; oral solution, 50 micrograms/ml; injection, 250 micrograms/ml in 2-ml ampoule.

*hydrochlorothiazide

tablet, 25 mg, 50 mg.

12.5 Antithrombotic drugs

acetylsalicylic acid

tablet, 100 mg.

Complementary drug(s)

streptokinase

(C)

powder for injection, 100,000 IU, 750,000 IU in vial.

12.6 Lipid-lowering agents

lipid-lowering agents*

HMG-CoA reductase inhibitors, often referred to as "statins" are a family of potent and effective lipid-lowering drugs with a good tolerability profile. Several of them have now been shown to reduce fatal and non-fatal myocardial infarction, stroke, the need for coronary by-pass surgery and all-cause mortality.

13.1 Antifungal drugs

benzoic acid + salicylic acid

ointment or cream, 6% + 3%.

*miconazole nitrate

ointment or cream, 2%.

sodium thiosulfate

solution, 15%.

Complementary drug(s)

selenium sulfide

(C)

detergent-based suspension, 2%.

13.2 Anti-infective drugs

*methylrosanilinium chloride (gentian violet)

aqueous solution, 0.5%; tincture, 0.5%.

neomycin sulfate + *bacitracin zinc

ointment, 5 mg + 500 IU.

*potassium permanganate

aqueous solution 1:10 000.

sulfadiazine silver

cream, 1%, in 500-g container.

13.3 Anti-inflammatory and antipruritic drugs

*betamethasone valerate

(3)

ointment or cream, 0.1% of betamethasone.

*calamine

lotion.

*hydrocortisone acetate

ointment or cream, 1%.

13.4 Astringent drugs

aluminium diacetate

solution, 13% for dilution.

13.5 Drugs affecting skin differentiation and proliferation

benzoyl peroxide

lotion or cream, 5%.

coal tar

solution, 5%.

dithranol

ointment, 0.1%-2%.

fluorouracil

ointment, 5%.

*podophyllum resin

(7)

solution, 10-25%.

salicylic acid

solution (topical) 5%.

urea

ointment or cream, 10%.

13.6 Scabicides and pediculicides

*benzyl benzoate

lotion, 25%.

permethrin

cream 5%; lotion 1%.

13.7 Ultraviolet blocking agents

Complementary drugs

broad-spectrum topical sun protection agent with activity against UVA and UVB

(C)

cream, lotion or gel.

14.1 Ophthalmic drugs

fluorescein sodium

eye drops, 1%.

*tropicamide

eye drops, 0.5%.

14.2 Radiocontrast media

barium sulfate

aqueous suspension.

*iopanoic acid

tablet, 500 mg.

*meglumine amidotrizoate

injection, 140-420 mg iodine/ml in 20-ml ampoule.

*propyliodone

oily suspension, 500-600 mg/ml in 20-ml ampoule*.

*This suspension is for administration only into the bronchial tree.

*sodium amidotrizoate

injection, 140-420 mg of iodine/ml in 20-ml ampoule.

Complementary drug(s)

*meglumine iotroxate

(C)

solution, 5-8 g iodine in 100-250 ml.

15.1 Antiseptics

*chlorhexidine digluconate

solution, 5% concentrate for dilution.

*povidone-iodine

solution, 10%.

15.2 Disinfectants

*chlorine base compound

powder for solution 0.1% available chlorine.

*chloroxylenol

solution, 5%.

glutaral

solution, 2%.

16. DIURETICS

*amiloride hydrochloride

(4, 7, 8)

tablet, 5 mg.

*furosemide

tablet, 40 mg; injection, 10 mg/ml in 2-ml ampoule.

*hydrochlorothiazide

tablet, 25 mg, 50 mg.

spironolactone

(8)

tablet, 25 mg.

Complementary drug(s)

*mannitol

(C)

injectable solution, 10%, 20%.

17.1 Antacids and other antiulcer drugs

aluminium hydroxide

tablet, 500 mg; oral suspension, 320 mg/5 ml.

*cimetidine

tablet, 200 mg; injection, 200 mg in 2-ml ampoule.

magnesium hydroxide

oral suspension, 550 mg of magnesium oxide/10 ml.

17.2 Antiemetic drugs

metoclopramide hydrochloride

tablet, 10 mg; injection, 5 mg/ml in 2-ml ampoule.

*promethazine hydrochloride

tablet, 10 mg, 25 mg; elixir or syrup, 5 mg/5 ml; injection, 25 mg/ml in 2-ml ampoule.

17.3 Antihaemorrhoidal drugs

*local anaesthetic, astringent and anti-inflammatory drug

ointment or suppository.

17.4 Anti-inflammatory drugs

hydrocortisone

retention enema.

17.4 Anti-inflammatory drugs

hydrocortisone acetate

suppository, 25 mg.

*sulfasalazine

(2)

tablet, 500 mg; suppository 500 mg; retention enema.

17.5 Antispasmodic drugs

*atropine sulfate

tablet, 0.6 mg; injection, 1 mg in 1-ml ampoule.

17.6 Laxatives

*senna

tablet, 7.5 mg (sennosides) (or traditional dosage forms).

17.7.1 Oral rehydration

oral rehydration salts (for glucose-electrolyte solution)

glucose, anhydrous 20.0 g/l.

*Trisodium citrate dihydrate may be replaced by sodium bicarbonate (sodium hydrogen carbonate) 2.5g/l. However, as the stability of this latter formulation is very poor under tropical conditions, it is only recommended when manufactured for immediate use.

17.7.2 Antidiarrhoeal (symptomatic) drugs

*codeine phosphate

(1a)

tablet, 30 mg.

18.1 Adrenal hormones and synthetic substitutes

*dexamethasone

tablet 500 micrograms, 4 mg.

*dexamethasone disodium phosphate

injection 4 mg of dexamethasone phosphate in 1-ml ampoule.

hydrocortisone sodium succinate

powder for injection, 100 mg of hydrocortisone in vial.

*prednisolone

tablet 1 mg, 5 mg.

Complementary drug(s)

fludrocortisone acetate

(C)

tablet, 100 micrograms.

18.2 Androgens

Complementary drug

testosterone enantate

(C) (2)

injection, 200 mg in 1-ml ampoule.

18.3.1 Hormonal contraceptives

*ethinylestradiol + *levonorgestrel

tablets 30 micrograms + 150 micrograms.

*ethinylestradiol + *norethisterone

tablet, 35 micrograms + 1.0 mg.

*ethinylestradiol + *levonorgestrel

(C)

50 micrograms + 250 micrograms (pack of four).

*levonorgestrel

(B)

tablets, 30 micrograms.

medroxyprogesterone acetate

(B) (7, 8)

depot injection, 150 mg/ml in 1-ml vial.

norethisterone enantate

(B) (7, 8)

oily solution, 200 mg/ml in 1-ml ampoule.

18.3.2 Intrauterine devices

copper-containing device

18.3.3 Barrier methods

condoms with or without spermicide (nonoxinol)

diaphragms with spermicide (nonoxinol)

18.4 Estrogens

*ethinylestradiol

tablet, 10 micrograms, 50 micrograms.

18.5 Insulins and other antidiabetic agents

*glibenclamide

tablets, 2.5 mg, 5 mg.

insulin (soluble)

injection, 40 IU/ml in 10-ml vial, 100 IU/ml in 10-ml vial.

intermediate-acting insulin (compound insulin zinc suspension)

injection, 40 IU of insulin/ml in 10 ml vial; 100 IU of insulin/ml in 10 ml vial.

metformin

tablet, 500 mg.

18.6 Ovulation inducers

*clomifene citrate

(2, 8)

tablet, 50 mg.

18.7 Progestogens

norethisterone

tablet, 5 mg.

Complementary drug(s)

medroxyprogesterone acetate

(B)

tablet, 5 mg.

18.8 Thyroid hormones and antithyroid drugs

levothyroxine sodium

tablet, 50 micrograms, 100 micrograms.

potassium iodide

tablet, 60 mg.

*propylthiouracil

tablet, 50 mg.

19.1 Diagnostic agents

All tuberculins should comply with the WHO Requirements for Tuberculins (Revised 1985). WHO Technical Report Series, No. 745, 1987, Annex 1.

tuberculin, purified protein derivative (PPD)

injection.

19.2 Sera and immunoglobulins*

All plasma fractions should comply with the WHO Requirements for the Collection, Processing and Quality Control of Blood, Blood Components and Plasma Derivatives (Revised 1992). WHO Technical Report Series, No. 840, 1994, Annex 2.

anti-D immunoglobulin (human)

injection, 250 micrograms in single-dose vial.

antiscorpion sera

injection.

*antitetanus immunoglobulin (human)

injection, 500 IU in vial.

antivenom serum

injection.

diphtheria antitoxin

injection, 10,000 IU, 20,000 IU in vial.

immunoglobulin, human normal

(2)

intramuscular injection.

immunoglobulin, human normal

(2, 8)

intravenous injection.

*rabies immunoglobulin

injection, 150 IU/ml.

19.3.1 For universal immunization

BCG vaccine (dried)

injection.

diphtheria-pertussis-tetanus vaccine

injection.

diphtheria-tetanus vaccine

injection.

hepatitis B vaccine

injection.

measles vaccine

injection.

measles-mumps-rubella vaccine

injection.

poliomyelitis vaccine (inactivated)

injection.

poliomyelitis vaccine (live attenuated)

oral solution.

tetanus vaccine

injection.

tetanus-diphtheria (Td)

injection.

19.3.2 For specific groups of individuals

influenza vaccine

injection.

meningococcal vaccine

injection.

rabies vaccine

injection (in cell culture).

rubella vaccine

injection.

typhoid vaccine

injection.

yellow fever vaccine

injection.

20. MUSCLE RELAXANTS (PERIPHERALLY ACTING) AND CHOLINESTERASE INHIBITORS

*alcuronium chloride

(2)

injection, 5 mg/ml in 2-ml ampoule.

*neostigmine bromide

tablet, 15 mg.

*neostigmine metilsulfate

injection, 500 micrograms in 1-ml ampoule; 2.5 mg in 1-ml ampoule.

pyridostigmine bromide

(2, 8)

tablet, 60 mg; injection, 1 mg in 1-ml ampoule.

suxamethonium chloride

(2)

injection, 50 mg/ml in 2-ml ampoule; powder for injection.

Complementary drug(s)

vecuronium bromide

(C)

powder for injection, 10 mg in vial.

21.1 Anti-infective agents

*gentamicin sulfate

solution (eye drops), 0.3%.

*idoxuridine

solution (eye drops), 0.1%; eye ointment, 0.2%.

silver nitrate

solution (eye drops), 1%.

*tetracycline hydrochloride

eye ointment, 1%.

21.2 Anti-inflammatory agents

*prednisolone sodium phosphate

eye drops, 0.5%.

21.3 Local anaesthetics

*tetracaine hydrochloride

solution (eye drops), 0.5%.

21.4 Miotics and antiglaucoma drugs

acetazolamide

tablet, 250 mg.

*pilocarpine hydrochloride

solution (eye drops), 2%, 4%.

*pilocarpine nitrate

solution (eye drops), 2%, 4%.

*timolol maleate

solution (eye drops), 0.25%, 0.5%.

21.5 Mydriatics

atropine sulfate

solution (eye drops), 0.1%; solution 0.5%, 1%.

Complementary drug(s)

epinephrine hydrochloride

(A)

solution (eye drops), 2% of epinephrine.

22.1 Oxytocics

*ergometrine hydrogen maleate

tablet, 200 micrograms; injection, 200 micrograms in 1-ml ampoule.

oxytocin

injection, 10 IU in 1-ml ampoule.

22.2 Antioxytocics

*salbutamol sulfate

(2)

tablet, 4 mg of salbutamol; injection, 50 micrograms of salbutamol/ml in 5-ml ampoule.

23. PERITONEAL DIALYSIS SOLUTION

intraperitoneal dialysis solution (of appropriate composition)

parenteral solution.

24.1 Drugs used in psychotic disorders

*chlorpromazine hydrochloride

tablet, 100 mg; syrup, 25 mg/5ml; injection, 25 mg/ml in 2-ml ampoule.

*fluphenazine decanoate

(5)

injection, 25 mg in 1-ml ampoule.

*fluphenazine enantate

(5)

injection, 25 mg in 1-ml ampoule.

*haloperidol

tablet, 2 mg, 5 mg; injection, 5 mg in 1-ml ampoule.

24.2.1 Drugs used in depressive disorders

*amitriptyline hydrochloride

tablet, 25 mg.

24.2.2 Drugs used in bipolar disorders

carbamazepine

(10, 11)

scored tablet, 100 mg, 200 mg.

lithium carbonate

(2, 4)

capsule or tablet, 300 mg.

sodium valproate

(7, 11)

enteric coated tablet, 200 mg, 500 mg.

24.3 Drugs used in generalized anxiety and sleep disorders

*diazepam

(1b)

scored tablet, 2 mg, 5 mg.

24.4 Drugs used for obsessive compulsive disorders and panic attacks

clomipramine hydrochloride

capsules, 10 mg, 25 mg.

25.1 Antiasthmatic drugs

*aminophylline

(2)

injection, 25 mg/ml in 10 ml ampoule.

*beclometasone dipropionate

inhalation (aerosol), 50 micrograms per dose; 250 micrograms per dose.

*epinephrine hydrochloride

injection, 1 mg of epinephrine in 1-ml ampoule.

*epinephrine hydrogen tartrate

injection, 1 mg of epinephrine in 1-ml ampoule.

*ipratropium bromide

inhalation, 20 micrograms/metered dose.

*salbutamol sulfate

tablet, 2 mg, 4 mg of salbutamol; inhalation (aerosol), 100 micrograms of salbutamol per dose; syrup, 2 mg of salbutamol/5 ml; injection, 50 micrograms of salbutamol/ml in 5-ml ampoule; respirator solution for use in nebulizers, 5 mg of salbutamol/ml.

*theophylline

(10, 11)

tablet, 100 mg, 200 mg.

Complementary drug(s)

*sodium cromoglicate

(B)

inhalation (aerosol), 20 mg per dose.

25.2 Antitussives

*dextromethorphan hydrobromide

(1a)

oral solution, 3.5 mg/5 ml.

26.1 Oral

oral rehydration salts (for glucose-electrolyte solution)

see section 17.7.1.

potassium chloride

powder for solution.

26.2 Parenteral

glucose

injectable solution, 5% isotonic, 50% hypertonic.

glucose with sodium chloride

injectable solution, 4% glucose, 0.18% sodium chloride (equivalent to Na+ 30 mmol/l, Cl- 30 mmol/l).

potassium chloride

(2)

solution, 11.2% in 20-ml ampoule, (equivalent to K+ 1.5 mmol/ml, Cl- 1.5 mmol/ml).

sodium chloride

injectable solution, 0.9% isotonic (equivalent to Na+ 154 mmol/l, Cl- 154 mmol/l); injectable solution, 0.18% (Na+ 30 mmol/l, Cl- 30 mmol/l) + glucose, 4%.

sodium hydrogen carbonate

injectable solution, 1.4% isotonic (equivalent to Na+ 167 mmol/l, HCO3- 167 mmol/l); solution, 8.4% in 10-ml ampoule (equivalent to NA+ 1000 mol/l, HCO3- 1000 mol/l).

26.2 Parenteral

*sodium lactate (compound)

injectable solution.

26.3 Miscellaneous

water for injection

2-ml, 5-ml, 10-ml ampoules.

27. VITAMINS AND MINERALS

ascorbic acid

tablet, 50 mg.

*ergocalciferol

capsule or tablet, 1.25 mg (50,000 IU); oral solution, 250 micrograms/ml (10,000 IU/ml).

iodine

(8)

capsule, 200 mg.

*nicotinamide

tablet, 50 mg.

pyridoxine hydrochloride

tablet, 25 mg.

*retinol palmitate

sugar-coated tablet, 10,000 IU (5.5 mg) of retinol; capsule, 200,000 IU (110 mg) of retinol; oral oily solution 100,000 IU/ml of retinol in multidose dispenser; water-miscible injection 100,000 IU (55 mg) of retinol in 2-ml ampoule.

riboflavin

tablet, 5 mg.

*sodium fluoride

in any appropriate formulation.

thiamine hydrochloride

tablet, 50 mg.

Complementary drug(s)

calcium gluconate

(C), (2, 8)

injection, 100 mg/ml in 10-ml ampoule.